Red grapes, blueberries may enhance immune function

Two compounds found in red grapes and blueberries may help boost the human immune system, a U. S. study said Tuesday. Resveratrol in red grapes and pterostilbene from blueberries could work with vitamin D to raise the expression of the human cathelicidin antimicrobial peptide, or CAMP gene, which is involved in immune function, researchers from the Oregon State University reported. "Out of a study of hundreds of compounds, just these two popped right out," Adrian Gombart, an associate professor in the university's college of science said in a statement. "Their synergy with vitamin D to increase CAMP gene expression was significant and intriguing. It's a pretty interesting interaction," Gombart said. Resveratrol has been the subject of dozens of studies for a range of possible benefits, from improving cardiovascular health to fighting cancer and reducing inflammation. This research is the first to show a clear synergy with vitamin D that increased CAMP expression by several times, the researchers said. The CAMP gene itself is also the subject of much study, as it has been shown to play a key role in the "innate" immune system, or the body's first line of defense and ability to combat bacterial infection. The innate immune response is especially important as many antibiotics increasingly lose their effectiveness. A strong link has been established between adequate vitamin D levels and the function of the CAMP gene, but the new research suggests that certain other compounds may play a role as well, the researchers reported in the journal Molecular Nutrition and Food Research. However, they cautioned that the findings were made in laboratory cell cultures and do not prove that similar results would occur as a result of dietary intake. Continued research could lead to a better understanding of how diet and nutrition affect immune function, and possibly lead to the development of therapeutically useful natural compounds that could boost the innate immune response, the researchers said in their report.