Arab Today, arab today apple or pear scientists discover new gene linked to your body shape
Last Updated : GMT 00:32:07
Arab Today, arab today
Arab Today, arab today

Apple or pear? Scientists discover new gene linked to your body shape

Arab Today, arab today

Arab Today, arab today Apple or pear? Scientists discover new gene linked to your body shape

Apple or pear?
Washington - XINHUA

Scientists have found a new gene linked to body fat distribution in research that may help explain why you have an apple or pear shape.
Researchers from the Duke University reported Monday in the U.S. journal Proceedings of the National Academy of Sciences that a gene called Plexin D1 could control both where fat is stored and how fat cells are shaped, known factors in health and even the risk of future disease.
"This work identifies a new molecular pathway that determines how fat is stored in the body, and as a result, affects overall metabolic health," said senior author John Rawls, associate professor of molecular genetics and microbiology at Duke University School of Medicine. "Moving forward, the components of that pathway can become potential targets to address the dangers associated with visceral fat accumulation."
The researchers chose zebrafish for this study since their transparent bodies were easy to observe and found those genetically engineered to lack Plexin D1 had less abdominal or visceral fat, the kind that lends some humans a characteristic apple shape, than their normal counterparts.
Previous research has shown that people with an apple shape are more likely to develop diabetes and heart disease than those who have bigger hips and thighs, also described as being pear-shaped.
The same effect was observed in zebrafish. Those who were knocked out of the gene were protected from insulin resistance, a precursor of diabetes, even after eating a high-fat diet.
And that may be because that the visceral fat tissue of the mutant zebrafish was composed of smaller, but more numerous cells, which the researchers said are known to decrease the risk of insulin resistance and metabolic disease in humans.
In contrast, their normal siblings had visceral fat tissue containing larger, but fewer fat cells of the kind known to be more likely to leak inflammatory substances that contribute to illness.
Bolstering the zebrafish findings, collaborators at the Karolinska Institute in Sweden analyzed human patient samples and showed that levels of Plexin D1 were higher in individuals with type 2 diabetes, suggesting it may play a similar role in humans.
The researchers also used mice to study the function of Plexin D1, but all of the animals altered to lack the gene died at birth.
Next, they planned to search for other genes as well as environmental factors that are involved in the biology of body fat, again using zebrafish models.
"Our results indicate that the genetic architecture of body fat distribution is shared between fish and humans, which represents about 450 million years of evolutionary divergence," Rawls said. " For these pathways to have been conserved for so long suggests that they are serving an important role."

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

Arab Today, arab today apple or pear scientists discover new gene linked to your body shape Arab Today, arab today apple or pear scientists discover new gene linked to your body shape

 



Arab Today, arab today
Arab Today, arab today Hats, scarves add beauty to women

GMT 19:10 2017 Friday ,17 February

Hats, scarves add beauty to women
Arab Today, arab today Tourist guide reveals methods of tourist attractions

GMT 17:46 2017 Saturday ,18 February

Tourist guide reveals methods of tourist attractions
Arab Today, arab today To release new antiques collection

GMT 20:33 2017 Friday ,17 February

To release new antiques collection
Arab Today, arab today Leader Omar Abdel Rahman dies in US prison

GMT 19:00 2017 Sunday ,19 February

Leader Omar Abdel Rahman dies in US prison
Arab Today, arab today Murder of 2 reporters in Dominican Republic

GMT 22:45 2017 Thursday ,16 February

Murder of 2 reporters in Dominican Republic
View News in Arabic - Education: كتب ومراجع وأبحاث
Arab Today, arab today
Arab Today, arab today
Arab Today, arab today Kidogo provides childcare for underserved

GMT 20:24 2017 Wednesday ,15 February

Kidogo provides childcare for underserved
Arab Today, arab today Tragic fluctuations of Bakhtiari's life revealed

GMT 06:50 2017 Wednesday ,15 February

Tragic fluctuations of Bakhtiari's life revealed
Arab Today, arab today London to tax old cars

GMT 14:06 2017 Friday ,17 February

London to tax old cars
Arab Today, arab today Pluto's unruly moons

GMT 06:31 2015 Thursday ,04 June

Pluto's unruly moons
Arab Today, arab today Competes Sweden and Germans by S90

GMT 22:36 2017 Thursday ,16 February

Competes Sweden and Germans by S90
Arab Today, arab today Porsche reveals new 2018 Panamera

GMT 17:31 2017 Wednesday ,15 February

Porsche reveals new 2018 Panamera
Arab Today, arab today Actress Nadeen Al Rassi views art as her entity

GMT 07:30 2017 Saturday ,18 February

Actress Nadeen Al Rassi views art as her entity
Arab Today, arab today Teach monkeys to recognize themselves in mirror

GMT 20:41 2017 Wednesday ,15 February

Teach monkeys to recognize themselves in mirror

GMT 07:05 2017 Friday ,17 February

Singer Diana Karzon will issue a new album soon

GMT 06:40 2017 Friday ,10 February

MP calls for removing text from Islamic story

GMT 13:16 2017 Tuesday ,14 February

First fashion model with Down syndrome

GMT 10:26 2017 Tuesday ,14 February

Emergency UN meeting in Harare

GMT 14:04 2017 Tuesday ,14 February

"Lagom" new Swedish concept in interior design

GMT 12:07 2017 Thursday ,16 February

Bite-mimicking malaria vaccine

GMT 09:03 2017 Thursday ,16 February

Tour guide praises women’s beaches

GMT 13:12 2015 Saturday ,09 May

Sheikh Sultan opens Sharjah Centre

GMT 21:42 2017 Sunday ,12 February

Rania al-Ghazali designs candles of bubbles
Arab Today, arab today
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube
arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday