Nikkei opened lower Wednesday as a pause of yen\'s slide. In the first 15 minutes of trading, the 225-issue Nikkei Stock Average fell 110.98 points, or 1.02 percent, from Tuesday to 10, 768.10. The broader Topix index of all First Section issues on the Tokyo Stock Exchange was down 5.53 points, or 0.61 percent, at 900. 69.