drug delivery system created to control cancer as chronic condition
Last Updated : GMT 06:49:16
Arab Today, arab today
Arab Today, arab today
Last Updated : GMT 06:49:16
Arab Today, arab today

Drug delivery system created to control cancer as chronic condition

Arab Today, arab today

Arab Today, arab today Drug delivery system created to control cancer as chronic condition

Oregon State University.
San Francisco - XINHUA

A group of researchers from the United States and the United Kingdom has created a new cancer drug delivery system that builds on a new approach known as "metronomic dosage regimen," which uses significantly lower doses of chemotherapeutic drugs but at more frequent time intervals.

"Our goal is to significantly reduce tumors, slow or stop their regrowth, and allow a person's body and immune system time to recover its health and natural abilities to fight cancer," Adam Alani, an associate professor in the Oregon State University (OSU)/Oregon Health & Science University College of Pharmacy, and lead author on a new study published in Chemistry of Materials, was quoted as explaining in a news release from OSU.

"I'm very optimistic this is possible, and that it could provide an entirely new approach to cancer treatment", said Alani.

While the approach has multiple goals of killing cancer cells, creating a hostile biological environment for their growth, reducing toxicity from the drug regimen and avoiding the development of resistance to the cancer drugs being used, the new system is designed to dramatically slow and control tumors on a long-term, sustained basis, not necessarily aiming for their complete elimination.

"This new system takes some existing cancer therapy drugs for ovarian cancer, delivers both of them at the same time and allows them to work synergistically," said Alani.

"Imagine if we could manage cancer on a long-term basis as a chronic condition, like we now do high blood pressure or diabetes. This could be a huge leap forward."

Most conventional cancer chemotherapy is based on the use of "maximum tolerable doses" of a drug, in an attempt to completely eliminate cancer or tumors. In some cases such as ovarian cancer, however, drug-free intervals are needed to allow patient recovery from side effects, during which tumors can sometimes begin to grow again or develop resistance to the drugs being used.

The types of cancers the "metronomic dosage regimen" may best lend itself to are those that are quite complex and difficult to treat with conventional regimens based on "maximum tolerable dose." This includes ovarian, sarcoma, breast, prostate, and lung cancers.

One example of the new approach, now in trial stages, is use of two drugs already common in ovarian cancer treatment, paclitaxel and rapamycin, but at levels a tenth to a third of the maximum tolerable dose. One drug attacks cancer cells; the other inhibits cancer cell formation and the growth of blood vessels at tumor sites.

The system developed in the research takes the process a step further. It attaches these drugs to polymer nanoparticles that migrate specifically into cancer cells and are designed to release the drugs at a particular level of acidity that is common to those cells. The low doses, careful targeting of the drugs and their ability to work in synergy at the same time appeared to greatly increase their effectiveness, while almost completely eliminating toxicity.

Source : XINHUA

arabstoday
arabstoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

drug delivery system created to control cancer as chronic condition drug delivery system created to control cancer as chronic condition

 



Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

drug delivery system created to control cancer as chronic condition drug delivery system created to control cancer as chronic condition

 



GMT 03:59 2012 Tuesday ,27 March

Wafaa Amer: Port Said events frustrate me

GMT 13:51 2016 Tuesday ,05 January

France begins 1-year commemorations

GMT 04:07 2017 Tuesday ,04 July

Chinese Navy ships in Oman on goodwill visit

GMT 08:40 2017 Friday ,06 October

Erdogan says Turkey will 'soon' close borders

GMT 06:10 2018 Wednesday ,24 January

Bahraini-Jordanian solar energy cooperation discussed

GMT 19:30 2017 Friday ,08 December

Princess Sabeeka receives UN Women executive director

GMT 16:50 2017 Wednesday ,26 April

Nina Olson cooks live at “Expo” Sharjah

GMT 17:10 2017 Thursday ,02 November

Hoora Health Centre expansion project inaugurated

GMT 09:27 2016 Wednesday ,30 November

President, VP & bin Zayed congratulate Albanian President

GMT 02:43 2017 Saturday ,11 March

Shaikh Hamdan's Instagram followers reach 5m

GMT 12:28 2016 Monday ,21 November

Coldplay charms India in anti-poverty concert
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2025 ©

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2025 ©

arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday