some breast cancers linked to cholesterol byproduct
Last Updated : GMT 06:49:16
Arab Today, arab today
Arab Today, arab today
Last Updated : GMT 06:49:16
Arab Today, arab today

Some breast cancers linked to cholesterol byproduct

Arab Today, arab today

Arab Today, arab today Some breast cancers linked to cholesterol byproduct

Washington - XINHUA

A byproduct of cholesterol may function like the hormone estrogen to fuel the growth of breast cancer in mice, and perhaps in people, according to a U.S. study. The study, which was released Thursday, shed light on the link between high cholesterol and breast cancer for the first time, especially in post-menopausal women. "A lot of studies have shown a connection between obesity and breast cancer, and specifically that elevated cholesterol is associated with breast cancer risk, but no mechanism has been identified," said senior author Donald McDonnell of Duke University, in a statement. "What we have now found is a molecule - - not cholesterol itself, but an abundant metabolite of cholesterol -- called 27HC that mimics the hormone estrogen and can independently drive the growth of breast cancer." According to the researchers, the hormone estrogen feeds an estimated 75 percent of all breast cancers, and they found that 27- hydroxycholesterol, or 27HC, behaved similarly to estrogen in animals. Using mouse models that are highly predictive of what occurs in humans, McDonnell and colleagues demonstrated the direct involvement of 27HC in breast tumor growth, as well as the aggressiveness of the cancer to spread to other organs. They also found that the activity of this cholesterol metabolite was inhibited when the animals were treated with antiestrogens or when supplementation of 27HC was stopped. To further explore the role of 27HC in tumor growth, the researchers turned to human breast cancer samples and found the most aggressive tumors had the highest levels of the enzyme that converts cholesterol to 27HC. They also noted that 27HC could be made in other places in the body and transported to the tumor. McDonnell said the findings suggest there may be a simple way to reduce the risk of breast cancer by keeping cholesterol in check, either with anti-cholesterol drugs such as statins or a healthy diet. The next steps for research include clinical studies to verify those potential outcomes, as well as studies to determine if 27HC plays a role in other cancers, McDonnell added. The findings were published in the U.S. journal Science.

arabstoday
arabstoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

some breast cancers linked to cholesterol byproduct some breast cancers linked to cholesterol byproduct

 



Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

some breast cancers linked to cholesterol byproduct some breast cancers linked to cholesterol byproduct

 



GMT 14:58 2017 Tuesday ,28 February

Humans spark most US wildfires

GMT 00:49 2017 Tuesday ,28 February

New vehicle scanner to ease Oman border rush

GMT 10:50 2018 Monday ,08 January

L'anza unveils sprayable styling paste Airpaste

GMT 16:40 2012 Monday ,20 February

New Ferrari Enzo

GMT 13:47 2013 Friday ,22 March

FM: Greece takeover process of Cypriot banks

GMT 19:13 2017 Monday ,16 October

6 wounded in USA oil rig blaze near New Orleans

GMT 16:34 2016 Sunday ,25 September

Pakistani air force jet crashes, killing pilot

GMT 20:53 2017 Wednesday ,14 June

Media council abandon complaint against writer

GMT 20:59 2017 Tuesday ,31 October

IMF official says Egypt's economy

GMT 15:19 2017 Wednesday ,29 November

Five things to watch out for in 2018
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2025 ©

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2025 ©

arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday