new research reveals how cat dander triggers allergic responses
Last Updated : GMT 06:49:16
Arab Today, arab today
Arab Today, arab today
Last Updated : GMT 06:49:16
Arab Today, arab today

New research reveals how cat dander triggers allergic responses

Arab Today, arab today

Arab Today, arab today New research reveals how cat dander triggers allergic responses

London - Arab Today

New research reveals how the most common cause of severe allergic reactions to cats, the Fel d 1 protein which is found in cat dander, triggers an allergic response. Scientists have discovered that when the cat protein Fel d 1 is in the presence of very low doses of the ubiquitous environmental bacterial toxin, lipopolysaccharide (LPS), it activates the pathogen recognition receptor Toll-like receptor 4. Until now, it was not understood how Fel d 1 generated such a large inflammatory response in the immune system. Allergic reactions are the result of the immune system overreacting to a perceived danger. Instead of identifying and responding to a harmful virus or bacteria, it misidentifies different allergens, including dander (microscopic pieces of animal skin often accompanied by dried saliva from grooming), as dangerous and mounts an immune response. In order to find out how Fel d 1 triggers these allergic reactions, the researchers exposed human cells to cat and dog dander proteins in the presence or absence of low levels of LPS. The researchers found that when the bacterial toxin LPS is present, it increases the signalling to the body’s immune system, intensifying the body’s inflammatory response to the cat protein Fel d 1. They also discovered that the part of the immune system that recognises the LPS contaminated Fel d 1  is the pathogen recognition receptor Toll-like receptor 4 (TLR4). (TLR4 also plays a role in a heightened immune response, and subsequent allergic reaction, to dust mite allergens and as well as the metal nickel.) The researchers then used a drug which inhibits the TLR4 response and found that it blocks the effects of the cat dander protein on human cells, thereby preventing an inflammatory response. Dr Clare Bryant, lead author of the research from the University of Cambridge’s Department of Veterinary Medicine, said: “How cat dander causes such a severe allergic reaction in some people has long been a mystery. Not only did we find out that LPS exacerbates the immune response’s reaction to cat dander, we identified the part of immune system that recognises it, the receptor TLR4.” Additional research revealed that the dog allergen Can f 6 (a protein found in dog dander) also enhances LPS-induced activation of TLR4. The researchers believe that dog-allergy sufferers could also benefit from new drugs which inhibit TLR4. Dr Bryant continued: “As drugs have already been developed to inhibit the receptor TLR4, we are hopeful that our research will lead to new and improved treatments for cat and possibly dog allergy sufferers.” The research was funded by the Wellcome Trust and the Medical Research Council (MRC). It was published in the The Journal of Immunology.

arabstoday
arabstoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

new research reveals how cat dander triggers allergic responses new research reveals how cat dander triggers allergic responses

 



Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

new research reveals how cat dander triggers allergic responses new research reveals how cat dander triggers allergic responses

 



GMT 13:49 2017 Thursday ,08 June

Boko Haram kills 11 in NE Nigeria attacks: police

GMT 09:08 2017 Monday ,11 September

Palestinian court grants bail to prominent activist

GMT 00:06 2018 Wednesday ,24 January

Emirates signs agreement for 36 additional A380s

GMT 09:59 2018 Wednesday ,10 January

Pakistan reiterates solidarity with Saudi Arabia

GMT 23:01 2016 Wednesday ,30 November

21 killed in artillery shelling of eastern Aleppo

GMT 09:22 2016 Monday ,10 October

US troops in Kuwait came under 'suicide' attack

GMT 21:14 2017 Tuesday ,21 February

Tatas will lead, not follow

GMT 11:24 2017 Wednesday ,15 February

ISIS kidnapped 16 civilians from Anbar

GMT 19:30 2018 Wednesday ,31 October

King congratulates Antigua and Barbuda Governor-General

GMT 00:05 2017 Thursday ,28 December

Guterres extends mandate of UN-backed Lebanon tribunal
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2025 ©

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2025 ©

arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday