Arab Today, arab today anticancer agents discovered in plants
Last Updated : GMT 14:20:32
Arab Today, arab today
Arab Today, arab today

Anti-cancer agents discovered in plants

Arab Today, arab today

Arab Today, arab today Anti-cancer agents discovered in plants

Abu Dhabi - Arabstoday

In the United Arab Emirates, cancer accounts for 15% of all death. Breast cancer is the most frequently diagnosed cancer among women and ranks second as a cause of cancer death in women after lung cancer. Plants have been shown to be an excellent source of new drugs, including anticancer agents. Identification and development of new chemotherapeutic agents from plants have gained significant recognition in the field of cancer therapy and become a major area of experimental cancer research. Dr Rabah Iratni, Associate Professor in the Department of Biology, United Arab Emirates University (UAEU), established a laboratory three years back, to explore if a potent new anti-cancer drug could be found in our home garden, perhaps in the leaves, the blooms, or even the roots of a plant. Dr Rabah\'s research team began studying various types of plants extracts and pure naturally occurring phytochemicals in the search for new compounds that could provide more effective, less toxic ways to fight different forms of cancer with a focus on breast and lung cancer.  So far, the laboratory has evaluated numerous phytochemicals and extracts and many of them revealed to be highly effective against these cancer. Dr Rabah\'s stated, \"Recently, we have found that the leaf extract from the marjoram herb (Origanum Majorana), a worldwide spread plant with a long history of both culinary and traditional medicine, can inhibit the growth of cultured invasive breast cancer cells.\" These research findings were the result of a research project carried out by a national PhD student, Yusra al-Dhaheri, and have recently been published in the international scientific journal PloS ONE entitled \'Mitotic Arrest and Apoptosis in Breast Cancer Cells Induced by Origanum Majorana Extract: Up-regulation of TNF-α and Down-regulation of Survivin and Mutant\', and has also been reported in Nature Middle-East entitled \'A Herbal Treatment for Breast Cancer\'. \"We showed that Origanum extract (OME) elicited different effects on the invasive breast cancer cells. Lower concentrations of the extract blocked the breast cancer cells at the mitosis stage of cell division. On the other hand, higher concentrations triggered a massive cell death and caused severe depletion of the mutant \'tumor suppressor\' protein in these cells. It is noteworthy to mention that the mutant has been reported to play a key role in cancer cells resistance to certain anti-cancer drugs and thus is considered as a potential cancer-specific target for pharmacologic interventions. Hence, our findings provide strong evidence that Origanum Majorana  may be a promising chemo preventive and therapeutic candidate against cancer especially for highly invasive triple negative mutant breast cancer; thus validating its complementary and alternative medicinal use,\" added Dr Iratni. Dr Ali Rashid al-Noaimi, UAEU Vice Chancellor, commended the team of researchers and said, \"As a leading research-intensive University of International stature, our world-class faculty and exceptional students continue to demonstrate the abilities and strengths of this University in addressing the significant challenges faced world-wide and continue to contribute significantly in many areas in particular medical advancements. The very fact that this research has been published in such a highly regarded publications is testament to its importance, and testament to the brilliant work being done here at UAEU. We are very proud of their achievement.\" As a continuity of this OME related research, more findings are currently under consideration for publication in recognized international scientific journal. The effect of Salinomycin, an antibiotic isolated from the bacteria Streptomyces albus, on breast cancer was another interesting story coming from Dr Iratni\'s laboratory also published recently in another high quality international journal Biochemica Biophysical Acta.  \"Our team was the first to gain an insight into the underlying mechanism of these compound anti-cancer properties and senescence induction in invasive breast cancer cells. We found that Salinomycin was able to induce growth inhibition, permanent cell cycle arrest, apoptosis and senescence of breast cancer cells. Interestingly, we also showed that Salinomycin was able to enhance the anti-proliferative activity of conventional chemotherapy drugs,\" added Dr Iratni. Dr Iratni\'s research team composed of faculty members, PhD and master students have several other ongoing anti-cancer research projects being carried out by the Department of Biology in collaboration with Dr Samir Attoub from the College of Medicine and Health Sciences, UAEU.  Our main goal is to purify the anti-cancer bioactive compound(s) in these extracts. \"Such quantitative and qualitative outcomes could not have been achieved without the crucial financial support from UAEU and Emirates Foundation,\" said Dr Iratni.

arabstoday
arabstoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

Arab Today, arab today anticancer agents discovered in plants Arab Today, arab today anticancer agents discovered in plants

 



Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

Arab Today, arab today anticancer agents discovered in plants Arab Today, arab today anticancer agents discovered in plants

 



Arab Today, arab today
Arab Today, arab today Designer Aql Faqih aspires to innovation

GMT 18:41 2017 Friday ,20 October

Designer Aql Faqih aspires to innovation
Arab Today, arab today Malaysia Airlines picks new CEO

GMT 12:54 2017 Saturday ,21 October

Malaysia Airlines picks new CEO
Arab Today, arab today Etiquette expert underlines importance of gifts

GMT 17:52 2017 Sunday ,03 September

Etiquette expert underlines importance of gifts
Arab Today, arab today Residents get glimpse of Raqa in ruins

GMT 07:10 2017 Saturday ,21 October

Residents get glimpse of Raqa in ruins
Arab Today, arab today Hiring not part of Alibaba pledge

GMT 11:26 2017 Wednesday ,18 October

Hiring not part of Alibaba pledge
Arab Today, arab today
Arab Today, arab today
Arab Today, arab today World's deepest lake in peril

GMT 15:54 2017 Friday ,20 October

World's deepest lake in peril
Arab Today, arab today Ex-French minister Dati wants tough action

GMT 10:54 2017 Thursday ,19 October

Ex-French minister Dati wants tough action
Arab Today, arab today Delhi braces for pollution 'airpocalypse'

GMT 16:07 2017 Friday ,20 October

Delhi braces for pollution 'airpocalypse'
Arab Today, arab today The history of solar eclipses

GMT 05:16 2017 Sunday ,20 August

The history of solar eclipses
Arab Today, arab today EU raids automaker BMW

GMT 11:06 2017 Saturday ,21 October

EU raids automaker BMW
Arab Today, arab today Sweden to get biggest car factory

GMT 14:10 2017 Friday ,20 October

Sweden to get biggest car factory
Arab Today, arab today Actress Mona Zaki praises husband’s role

GMT 08:15 2017 Thursday ,19 October

Actress Mona Zaki praises husband’s role
Arab Today, arab today Massacre fears spark race

GMT 19:09 2017 Thursday ,19 October

Massacre fears spark race

GMT 08:57 2017 Wednesday ,18 October

Actress Shery Adel happy for Egypt’s qualification

GMT 18:15 2017 Monday ,16 October

British actress becomes fifth woman

GMT 16:53 2017 Tuesday ,05 September

Youssra depended on colored foam

GMT 16:00 2017 Wednesday ,18 October

Climate-disrupting volcanoes helped topple

GMT 10:46 2017 Saturday ,05 August

Nanis reveals simple ideas for home renovation

GMT 09:56 2017 Friday ,20 October

Privacy Groups Warn of Perils

GMT 08:04 2017 Thursday ,19 October

Second US judge orders freeze

GMT 17:12 2017 Monday ,07 August

Al-Shawaifi reveals secrets of total solar eclipse

GMT 20:46 2017 Thursday ,19 October

Qualcomm files lawsuits in China to ban iPhones

GMT 16:53 2017 Saturday ,02 September

Mai importance of gifts during Eid Al-Adha
Arab Today, arab today
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube
arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday