A bomb explosion in a market on Sunday killed 22 persons and wounded 45 others in Pakistan's Kurram tribal region near the Afghan border, ABC News reported.
The bomb exploded as the market in the town of Parachinar was crowded with shoppers buying warm clothes for winter, said Mahtab Hussain, a local government official.
Husain said some of the critically wounded people were airlifted to hospitals in other cities.
The explosion was caused by a remote-controlled bomb planted in the market, the two officials said.
Parachinar is the main town in the Kurram tribal region, which has been troubled by Islamic militant and sectarian violence.
Pakistan's military has carried out regular operations in the region to eliminate militants and control sectarian strife.
No one immediately claimed responsibility for the attack. Suspicion would likely fall on al Qaida and Pakistani Taliban-linked militant groups.
The Taliban and allied militants have been waging a war against the state for over a decade, killing tens of thousands of people.