Arab Today, arab today molecule clue to memory decline
Last Updated : GMT 05:42:12
Arab Today, arab today
Arab Today, arab today

Inhibiting B2M improved learning

Molecule clue to memory decline

Arab Today, arab today

Arab Today, arab today Molecule clue to memory decline

Age may be linked to cognitive decline
Paris - Arab Today

A molecule that accumulates in the blood with age may be linked to cognitive decline, said scientists Monday who mooted hopes of a memory-restoring treatment.

The protein, dubbed B2M, is found in higher concentrations in the blood and cerebral spinal fluid of ageing humans, they said.

And in mice, inhibiting B2M improved learning and memory in lab experiments.

"We are very excited about the findings because it indicates that there are two ways to potentially reverse age-related cognitive impairments," study co-author Saul Villeda of the University of California San Francisco told AFP.

"One is to introduce pro-youthful blood factors and the other is to therapeutically target pro-ageing factors" like B2M, he said by email.

Villeda had participated in another study, published last year, which found that injections of juvenile mouse blood boosted learning and memory in older rodents.

Scientists measure the animals' ability to remember cues indicating the position of hidden platforms in water, similar to having to recall physical landmarks to remember where you left your car in a parking lot -- a function that declines with age.

Old mice who received young blood in the first study could find the hidden platforms easier -- though it was not clear why or how.

Ageing is associated with a progressive decline in cognitive function, and slower regeneration of message-relaying neurons in the brain.

"Ageing remains the most dominant risk factor for dementia-related neurodegenerative diseases, such as Alzheimer's disease," wrote the authors of the new research published in the journal Nature Medicine.

"As such, it is imperative to gain mechanistic insight into what drives ageing... in the brain in order to counteract vulnerability to cognitive dysfunction."

From the latest work, it appears that B2M, a protein involved in immunity, may help explain the young blood effect on memory.

B2M injections impaired the learning ability, memory, and neuron growth of lab mice, the team wrote. But the effect was "reversible" by stopping the injections.

In another experiment, the scientists eliminated B2M genetically in mice, and "observed that the old mice lacking B2M did not develop memory loss," said Villeda.

This all implied the molecule "could be targeted to potentially restore cognitive ability in the elderly," he added.

The next step would be to develop a molecule that can either block the protein, or help remove it from old human blood.

B2M has previously also been found in elevated levels in the cerebral spinal fluid of dementia patients.
Source: AFP

arabstoday
arabstoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

Arab Today, arab today molecule clue to memory decline Arab Today, arab today molecule clue to memory decline

 



Arab Today, arab today

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

Arab Today, arab today molecule clue to memory decline Arab Today, arab today molecule clue to memory decline

 



Arab Today, arab today France defies terrorism through tourism

GMT 15:18 2017 Saturday ,20 May

France defies terrorism through tourism

GMT 09:55 2017 Saturday ,15 April

Dino ancestors looked like crocodiles: study

GMT 10:42 2017 Tuesday ,28 March

Disaster costs nearly double to $175bn

GMT 07:25 2017 Friday ,24 March

Yemen children dream of school

GMT 12:03 2017 Tuesday ,14 March

Yemeni official warns education is under threat

GMT 10:24 2017 Tuesday ,14 March

Sheikha Lubna: Parents have responsibility

GMT 20:28 2017 Friday ,10 March

Urges government to pay their education expenses
View News in Arabic - Education: التعليم أخبار
Arab Today, arab today
Arab Today, arab today
Arab Today, arab today Mozambique's gas boom dream under threat

GMT 16:29 2017 Monday ,08 May

Mozambique's gas boom dream under threat
Arab Today, arab today Prepares to give stargazers an eyeful

GMT 13:38 2017 Monday ,06 March

Prepares to give stargazers an eyeful
Arab Today, arab today Jaguar displays XF Sportbrake line

GMT 14:36 2017 Monday ,08 May

Jaguar displays XF Sportbrake line
Arab Today, arab today BMW sees forecasts in reach

GMT 09:04 2017 Thursday ,04 May

BMW sees forecasts in reach
Arab Today, arab today Climate science: Bad news gets worse

GMT 08:48 2017 Saturday ,06 May

Climate science: Bad news gets worse
Arab Today, arab today
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube
arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday