Arab Today, arab today rotavirus vaccines linked to small risk of intussusception
Last Updated : GMT 21:10:43
Arab Today, arab today
Arab Today, arab today

Rotavirus vaccines linked to small risk of intussusception

Arab Today, arab today

Arab Today, arab today Rotavirus vaccines linked to small risk of intussusception

Washington - XINHUA

The second generation vaccines against rotavirus, the most common cause of severe childhood diarrhea worldwide, are associated with a small increased risk of a rare intestinal disorder called intussusception that may require surgery, two U.S. studies suggested Tuesday. However, the benefits of the vaccines, Merck's RotaTeq (RV5) and GlaxoSmithKline's Rotarix (RV1), outweigh this possible small risk, according to the two papers published online by the New England Journal of Medicine. Rotavirus infection causes an estimated 527,000 deaths in children less than five years of age each year, according to the World Health Organization (WHO). The first licensed rotavirus vaccine known as RotaShield, however, was forced to withdraw in 1999, only one year after licensure in the U.S., because of increased risk of intussusception. RotaTeq and Rotarix were subsequently licensed, one in 2006, the other in 2008. The two are now recommended by the WHO for immunization of children worldwide. Both vaccines have shown tremendous health benefits. For example, before they were available in the U.S. in 2006, rotavirus was responsible for more than 200,000 emergency room visits and 55, 000 to 70,000 hospitalizations of young children each year. Also, 20 to 60 children died each year. But since 2006, hospitalizations and emergency room visits have decreased by more than 80 percent among immunized children. But in a seven-year study of RotaTeq, researchers from Harvard Medical School and Harvard Pilgrim Health Care Institute looked at data from 507,874 first doses and 1,277,556 total doses and found an excess risk of 1.5 cases per 100,000 recipients after the first dose, which was roughly one tenth the risk associated with the first-generation vaccine. However, no significant increase in risk was seen after the second or third dose. In a five-year of Rotarix, researchers from the U.S. Centers for Disease Control and Prevention (CDC) looked at 207,955 doses, including 115,908 first doses and 92,047 second doses, and identified 5.3 extra cases of intussusception within seven days after the administration of either dose. Only 0.72 cases would be expected per 100,000 unvaccinated young children. In an accompanying editorial, Roger Glass of the National Institutes of Health and Umesh Parashar of the CDC wrote that the results of the studies should be interpreted with caution. "What, then, is the message for the physician or nurse who administers rotavirus vaccines, and what is the implication for vaccine policy in developed countries?" the two asked. "Certainly, the abundance of evidence in the United States and beyond indicates that intussusception can occur as a result of vaccination with either RV5 or RV1, but the risk is low, on the order of approximately 1 to 5 cases per 100,000 infants, with wide confidence limits." "Many questions remain to be resolved ... (however,) the public health benefits of rotavirus vaccines ... are likely to be substantial and outweigh a small risk of intussusception," they added.

arabstoday
arabstoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

Arab Today, arab today rotavirus vaccines linked to small risk of intussusception Arab Today, arab today rotavirus vaccines linked to small risk of intussusception

 



Arab Today, arab today

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

Arab Today, arab today rotavirus vaccines linked to small risk of intussusception Arab Today, arab today rotavirus vaccines linked to small risk of intussusception

 



Arab Today, arab today France defies terrorism through tourism

GMT 15:18 2017 Saturday ,20 May

France defies terrorism through tourism
Arab Today, arab today Mai Al-Jeddawi presents décor ideas for Ramadan
View News in Arabic - Education: تقارير وملفات
Arab Today, arab today
Arab Today, arab today

GMT 09:49 2017 Tuesday ,02 May

Girl barred from Malaysia chess competition

GMT 17:59 2017 Monday ,12 June

Designer Rania Adel reveals her new collection

GMT 08:48 2017 Saturday ,06 May

Climate science: Bad news gets worse

GMT 16:25 2017 Sunday ,04 June

“Suhoor” is basic meal for fasting

GMT 06:31 2015 Thursday ,04 June

Pluto's unruly moons

GMT 11:09 2017 Sunday ,25 June

HUAWEI P10 the ‘guru’ of portrait shots
Arab Today, arab today
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube
arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday