Arab Today, arab today research finds new way to fight malaria drug resistance
Last Updated : GMT 15:09:25
Arab Today, arab today
Arab Today, arab today

Research finds new way to fight malaria drug resistance

Arab Today, arab today

Arab Today, arab today Research finds new way to fight malaria drug resistance

Canberra - XINHUA

An anti-malarial treatment that lost its status as the leading weapon against the deadly disease could be given a new lease of life, with new research indicating it simply needs to be administered differently. The Australian National University (ANU) said in a press release on Tuesday that the findings could revive the use of the cheap anti-malarial drug chloroquine in treating and preventing the mosquito-bourne disease, which claims the lives of more than half a million people each year around the world. The parasite that causes malaria has developed resistance to chloroquine, but research carried out at the ANU and Germany's University of Heidelberg has shown that the parasite protein that causes resistance has an Achilles' heel. "We studied diverse versions of this protein and in all cases found that it is limited in its capacity to remove the drug from the parasite," said malaria researcher Dr Rowena Martin, from the ANU Research School of Biology. "This means malaria could once again be treated with chloroquine if it is administered twice-daily, rather than just once a day." Once hailed as a wonder drug, chloroquine is still used in developing nations in the South Pacific, Africa, Asia and South America, but has been withdrawn from use in many developed countries. Dr Martin and her colleagues also revealed how the protein may have developed resistance to chloroquine. "We found that the protein gains the ability to move chloroquine out of the parasite through one of two evolutionary pathways, but that this process is rigid one wrong turn and the protein is rendered useless," she said. "This indicates that the protein is under conflicting pressures, which is a weakness that could be exploited in future antimalarial strategies." Martin said the findings, published in the latest Proceedings of the National Academy of Sciences of the United States, could be used to help millions of people in developing nations who are at risk of catching malaria. She said that there is also potential to apply the findings to several chloroquine-like drugs that are also becoming less effective as the malaria parasite builds up resistance. Martin, however, does not recommend taking large doses of chloroquine. "The key is to increase the frequency of chloroquine administration, for example by taking a standard dose in the morning and another at night. If you take too much all at once it can kill you," she cautioned.

arabstoday
arabstoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

Arab Today, arab today research finds new way to fight malaria drug resistance Arab Today, arab today research finds new way to fight malaria drug resistance

 



Arab Today, arab today

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

Arab Today, arab today research finds new way to fight malaria drug resistance Arab Today, arab today research finds new way to fight malaria drug resistance

 



Arab Today, arab today France defies terrorism through tourism

GMT 15:18 2017 Saturday ,20 May

France defies terrorism through tourism
Arab Today, arab today Mai Al-Jeddawi presents décor ideas for Ramadan
Arab Today, arab today Sally Shaheen considers hosting a political show
View News in Arabic - Education: تقارير وملفات
Arab Today, arab today
Arab Today, arab today
Arab Today, arab today
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube
arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday