Arab Today, arab today researchers isolate target for therapies to treat cocaine addiction
Last Updated : GMT 22:20:05
Arab Today, arab today
Arab Today, arab today

Researchers isolate target for therapies to treat cocaine addiction

Arab Today, arab today

Arab Today, arab today Researchers isolate target for therapies to treat cocaine addiction

Cocaine addiction
Washington - UPI

A new study by researchers at Massachusetts General Hospital suggests a newly identified neural target is key in contributing to cocaine cravings following a period of abstinence.
A litany of genes and neural receptors have been implicated in the science of addiction. But in studying the behaviors of lab mice, scientists found that by simply changing a single amino acid in a subunit of a receptor protein that influences cravings -- a protein known as the AMPA receptor -- they could reduce cravings and the likelihood of a drug relapse.
"The critical role of the AMPA receptor in cocaine addiction is clear," Dr. Ghazaleh Sadri-Vakili, director of the NeuroEpigenetics Laboratory at Mass General and senior author of the new study, explained in a press release. "We have known that activation of the AMPA receptor in the nucleus accumbens -- an area of the brain important for drug addiction -- promotes the resumption of cocaine seeking in animal models, and this study identifies an increased contribution of calcium-permeable AMPA receptors to this process."
In most human brains, AMPA receptors are not calcium-permeable. But chronic cocaine use disrupts glutamate editing in the nucleus accumbens. Glutamate editing determines whether the subunits of AMPA receptors, particular subunit GluA2, are calcium-permeable or not.
In the latest study, mice were given cocaine for 21 days, then were withheld from the drug for 10 days. After their cocaine binge, the mice were found to have fewer edited GluA2 subunits than drug-free animals, as well as less of the enzyme responsible for editing the subunits.
The changes seem to have isolated one of the major neural components in the processes of addiction, self control and relapse. Researchers predicted that by reversing the damage to the AMPA receptors, they could mitigate the chance of relapse.
After the ten days of abstinence, researchers gave half the mice a GluA2-editing enzyme called ADAR2. The over-expression of this enzyme upped the presence of edited GluA2 in the mice's brains and reduced the resumption of cocaine.
"Our findings support the novel hypothesis that calcium-permeable AMPA receptors containing unedited GluA2 subunits contribute to cocaine seeking and that repairing the deficient editing of GluA2, possibly by regulation of ADAR2 expression, could be a treatment strategy for cocaine addiction," concluded Sadri-Vakili.
The findings were detailed in a study published this week in the journal Molecular Psychiatry.

 

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

Arab Today, arab today researchers isolate target for therapies to treat cocaine addiction Arab Today, arab today researchers isolate target for therapies to treat cocaine addiction

 



Arab Today, arab today
Arab Today, arab today Accessories designer reveals her new collection

GMT 18:57 2017 Tuesday ,21 March

Accessories designer reveals her new collection
Arab Today, arab today Laptop ban sparks ire

GMT 09:02 2017 Thursday ,23 March

Laptop ban sparks ire
Arab Today, arab today Sheds light on major steps in 12-year career

GMT 06:07 2017 Monday ,27 February

Sheds light on major steps in 12-year career
Arab Today, arab today Dozens dead in US-led Syria strikes

GMT 08:35 2017 Thursday ,23 March

Dozens dead in US-led Syria strikes
Arab Today, arab today AT&T, Verizon join Google ad boycott

GMT 10:30 2017 Thursday ,23 March

AT&T, Verizon join Google ad boycott
View News in Arabic - Education: كتب ومراجع وأبحاث
Arab Today, arab today
Arab Today, arab today
Arab Today, arab today Yemeni official warns education is under threat

GMT 12:03 2017 Tuesday ,14 March

Yemeni official warns education is under threat
Arab Today, arab today Number of unwedded girls amounts to 2.5m

GMT 22:00 2017 Thursday ,23 March

Number of unwedded girls amounts to 2.5m
Arab Today, arab today 2017 already marked

GMT 15:25 2017 Tuesday ,21 March

2017 already marked
Arab Today, arab today Prepares to give stargazers an eyeful

GMT 13:38 2017 Monday ,06 March

Prepares to give stargazers an eyeful
Arab Today, arab today Audi RS 5 Coupe acquires new design

GMT 13:22 2017 Thursday ,23 March

Audi RS 5 Coupe acquires new design
Arab Today, arab today Renault Trezor wins design award

GMT 11:56 2017 Tuesday ,21 March

Renault Trezor wins design award
Arab Today, arab today Donia Abdel Aziz participates in "Game of Silence"

GMT 07:12 2017 Tuesday ,21 March

Donia Abdel Aziz participates in "Game of Silence"
Arab Today, arab today Mexico threatens to ditch US corn imports

GMT 10:34 2017 Tuesday ,21 March

Mexico threatens to ditch US corn imports

GMT 07:39 2017 Monday ,20 March

Dalia Mustafa believes in the presence of ghosts

GMT 19:27 2017 Saturday ,11 March

Boualsof launches "Priestess Kahina" collection

GMT 16:41 2017 Monday ,20 March

Preserving the memory of glaciers

GMT 19:45 2017 Monday ,20 February

Sarah Belamesh designs antiques of "ceramic"

GMT 13:11 2017 Tuesday ,21 March

Web-based counseling lowers blood pressure

GMT 10:18 2017 Tuesday ,21 March

Kuwait's tourism industry to be worth

GMT 06:31 2015 Thursday ,04 June

Pluto's unruly moons

GMT 22:39 2017 Thursday ,09 March

Zuhair Murad presents his new collection "Resorts"
Arab Today, arab today
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube
arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday