researchers isolate target for therapies to treat cocaine addiction
Last Updated : GMT 13:03:42
Arab Today, arab today
Arab Today, arab today

Researchers isolate target for therapies to treat cocaine addiction

Arab Today, arab today

Arab Today, arab today Researchers isolate target for therapies to treat cocaine addiction

Cocaine addiction
Washington - UPI

A new study by researchers at Massachusetts General Hospital suggests a newly identified neural target is key in contributing to cocaine cravings following a period of abstinence.
A litany of genes and neural receptors have been implicated in the science of addiction. But in studying the behaviors of lab mice, scientists found that by simply changing a single amino acid in a subunit of a receptor protein that influences cravings -- a protein known as the AMPA receptor -- they could reduce cravings and the likelihood of a drug relapse.
"The critical role of the AMPA receptor in cocaine addiction is clear," Dr. Ghazaleh Sadri-Vakili, director of the NeuroEpigenetics Laboratory at Mass General and senior author of the new study, explained in a press release. "We have known that activation of the AMPA receptor in the nucleus accumbens -- an area of the brain important for drug addiction -- promotes the resumption of cocaine seeking in animal models, and this study identifies an increased contribution of calcium-permeable AMPA receptors to this process."
In most human brains, AMPA receptors are not calcium-permeable. But chronic cocaine use disrupts glutamate editing in the nucleus accumbens. Glutamate editing determines whether the subunits of AMPA receptors, particular subunit GluA2, are calcium-permeable or not.
In the latest study, mice were given cocaine for 21 days, then were withheld from the drug for 10 days. After their cocaine binge, the mice were found to have fewer edited GluA2 subunits than drug-free animals, as well as less of the enzyme responsible for editing the subunits.
The changes seem to have isolated one of the major neural components in the processes of addiction, self control and relapse. Researchers predicted that by reversing the damage to the AMPA receptors, they could mitigate the chance of relapse.
After the ten days of abstinence, researchers gave half the mice a GluA2-editing enzyme called ADAR2. The over-expression of this enzyme upped the presence of edited GluA2 in the mice's brains and reduced the resumption of cocaine.
"Our findings support the novel hypothesis that calcium-permeable AMPA receptors containing unedited GluA2 subunits contribute to cocaine seeking and that repairing the deficient editing of GluA2, possibly by regulation of ADAR2 expression, could be a treatment strategy for cocaine addiction," concluded Sadri-Vakili.
The findings were detailed in a study published this week in the journal Molecular Psychiatry.

 

arabstoday
arabstoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

researchers isolate target for therapies to treat cocaine addiction researchers isolate target for therapies to treat cocaine addiction

 



Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

researchers isolate target for therapies to treat cocaine addiction researchers isolate target for therapies to treat cocaine addiction

 



Arab Today, arab today
Arab Today, arab today Jordanian woman reveals her project

GMT 00:46 2017 Saturday ,11 November

Jordanian woman reveals her project
Arab Today, arab today The Big Apple bike boom

GMT 10:47 2017 Wednesday ,22 November

The Big Apple bike boom
Arab Today, arab today Keep kids busy at Thanksgiving gatherings

GMT 11:14 2017 Friday ,10 November

Keep kids busy at Thanksgiving gatherings
Arab Today, arab today Leaders of Russia, Iran, Turkey meet

GMT 10:12 2017 Wednesday ,22 November

Leaders of Russia, Iran, Turkey meet
Arab Today, arab today 'Advanced' cyber attack targets Saudi Arabia

GMT 10:18 2017 Wednesday ,22 November

'Advanced' cyber attack targets Saudi Arabia
Arab Today, arab today
Arab Today, arab today
Arab Today, arab today Australian academic's book pulled

GMT 15:20 2017 Monday ,13 November

Australian academic's book pulled
Arab Today, arab today May under Brexit pressure at EU reform summit

GMT 02:14 2017 Saturday ,18 November

May under Brexit pressure at EU reform summit
Arab Today, arab today Delhi half-marathon to go ahead

GMT 03:51 2017 Saturday ,18 November

Delhi half-marathon to go ahead
Arab Today, arab today The history of solar eclipses

GMT 05:16 2017 Sunday ,20 August

The history of solar eclipses
Arab Today, arab today Honda recalls 800,000 minivans

GMT 11:43 2017 Wednesday ,22 November

Honda recalls 800,000 minivans
Arab Today, arab today VW says will invest over 34bn euros

GMT 07:19 2017 Tuesday ,21 November

VW says will invest over 34bn euros
Arab Today, arab today Singer Jahda Wahba has unlimited ambitions

GMT 07:56 2017 Monday ,20 November

Singer Jahda Wahba has unlimited ambitions
Arab Today, arab today paObama climate envoy slams Trump's rejection

GMT 16:04 2017 Friday ,17 November

paObama climate envoy slams Trump's rejection

GMT 09:23 2017 Saturday ,18 November

Fedra happy for “Between Two Worlds” success

GMT 11:15 2017 Thursday ,16 November

Angola oil boss sacked by father's protege

GMT 18:41 2017 Friday ,20 October

Designer Aql Faqih aspires to innovation

GMT 11:38 2017 Wednesday ,15 November

Unloved vultures fight for their survival

GMT 11:49 2017 Thursday ,17 August

Egyptian artist presents new collection of designs

GMT 13:41 2017 Tuesday ,21 November

French choke up over proposal

GMT 00:44 2017 Monday ,20 November

Japanese regulators raid Airbnb

GMT 17:12 2017 Monday ,07 August

Al-Shawaifi reveals secrets of total solar eclipse

GMT 16:53 2017 Tuesday ,05 September

Youssra depended on colored foam
Arab Today, arab today
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube
arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday